In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7073-94-1 as follows. Quality Control of 1-Bromo-2-isopropylbenzene
To a solution of 1-bromo-2-isopropylbenzene (388 mg, 298 muL, 1.95 mmol) in dry THF, n-butyllithium (2.5 M in hexanes, 858 muL, 2.14 mmol) was added dropwise at -78 C. After 20 min at -78 C, dimethylformamide (157 mg, 166 muL, 2.14 mmol) was added and the reaction mixture was stirred at -78 C for 20 min and allowed to heat up to -10 C and stirred for 3 h more. Reaction was stopped by adding water (2.5 mL) and extracted with diethyl ether (3 * 100 mL). Combined organic layers were dried over anhydrous MgSO4, filtered, and evaporated, affording 2 with quantitative yield as a colorless oil (277 mg) showing spectral data according to its structure ( Ewing, 1974). It was used with no further purification.
According to the analysis of related databases, 7073-94-1, the application of this compound in the production field has become more and more popular.
Reference:
Article; Moreno-Ortega, Ana J.; Martinez-Sanz, Francisco J.; Lajarin-Cuesta, Rocio; De Los Rios, Cristobal; Cano-Abad, Maria F.; Neuropharmacology; vol. 95; (2015); p. 503 – 510;,
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