Electric Literature of 1073-06-9, The chemical industry reduces the impact on the environment during synthesis 1073-06-9, name is 1-Bromo-3-fluorobenzene, I believe this compound will play a more active role in future production and life.
1)3 Grignard reagent was prepared from 3-bromofluorobenzene (8.20 mL, 75.0 mmol) and magnesium (1.9095 g, 78.5 mmol) in dry THF (120 mL) in virtually quantitative yield. To a solution of ethyl formate (2.42 mL, 30.0 mmol) in dry THF (60 mL) a solution of Grignard reagent solution was slowly added at 0 C. After 1 h warming to room temperature, the reaction mixture was quenched with sat. NH4Cl aq. The organic layer was separated and the aqueous layer was extracted with ethyl acetate. The combined organic layer was dried over MgSO4, and filtered. The filtrate was concentrated in vacuo. The resulting residue was purified by column chromatography on silica gel (hexane/ ethyl acetate = 30/1) to afford bis(3-fluorophenyl)methanol. Yellow oil (6,6738g, quant.). 1H NMR (500 MHz, CDCl3) delta 7.34-7.27 (m, 2H), 7.17-7.04 (m, 4H), 7.02-6.93 (m, 2H), 5.81 (d, J = 3.5 Hz, 1H), 2.32 (d, J = 3.5 Hz, 1H) 4
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-3-fluorobenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Tanaka, Kenta; Kishimoto, Mami; Hoshino, Yujiro; Honda, Kiyoshi; Tetrahedron Letters; vol. 59; 19; (2018); p. 1841 – 1845;,
Bromide – Wikipedia,
bromide – Wiktionary