Application of 141474-37-5,Some common heterocyclic compound, 141474-37-5, name is 2,4-Dibromo-6-fluoroaniline, molecular formula is C6H4Br2FN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 1L round bottom flask, 2,4-dibromo-6-fluoroaniline 30 g (111.56 mmol), phenylboronic acid-d5 31.2 g (245.44 mmol), potassium carbonate (K2CO3) 61.9 g (446.27 mmol), tetrakis Triphenylphosphine palladium (Pd(PPh3)4) 2.6 g (2.20 mmol), water 120 mL, toluene 300 mL and tetrahydrofuran 300 mL was added and refluxed for 24 hours. When the reaction was completed, the resultant product was layer-separated to remove the aqueous layer, the organic layer was separated and concentrated under reduced pressure, and then the solid obtained by separation by column chromatography using hexane and dichloromethane as a development solvent was dried, yielding 24.2 g. 79.4% of a white solid was obtained.
The synthetic route of 141474-37-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SFC Ltd.; Lee Sang-hae; Sim So-yeong; Ryu Se-jin; (30 pag.)KR102121582; (2020); B1;,
Bromide – Wikipedia,
bromide – Wiktionary