Adding a certain compound to certain chemical reactions, such as: 49764-63-8, name is 4,5-Dibromobenzene-1,2-diamine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 49764-63-8, Recommanded Product: 49764-63-8
Add to a pre-dried 100ml two-necked bottle, Triphenylamine 4-boronic acid (773mg),4,5-Dibromo-o-diaminobenzene (138 mg), Pd(PPh3)2Cl2 (40 mg), K2CO3 (424 mg). After nitrogen protection, 30 ml of toluene and 2 ml of deionized water were added, the temperature was raised to 80 C, and the reaction was carried out for 24 hours. After the reaction, the mixture was washed and extracted with dichloromethane and water several times. The organic phase was collected, dried over anhydrous magnesium sulfate, concentrated under reduced pressure, and then purified by column chromatography. 200-300 mesh silica gel was used as a stationary phase, and a dichloromethane / petroleum ether volume ratio 3: 1 mixture was used as a mobile phase to elute. The eluate containing the target compound was collected, and the solvent was distilled off under reduced pressure and dried. 488 mg of pink solid was obtained by thin layer chromatography with a yield of 82%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4,5-Dibromobenzene-1,2-diamine, and friends who are interested can also refer to it.
Reference:
Patent; Zhejiang University of Technology; Li Weijun; Xu Ning; Chen Zhangxin; Zhang Cheng; (14 pag.)CN110713493; (2020); A;,
Bromide – Wikipedia,
bromide – Wiktionary