Related Products of 2862-39-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2862-39-7, name is 2-Bromo-N,N-dimethylethanamine hydrobromide belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: To a stirred solution of 6-(4-chlorophenyl)-5-(3, 8-dimethyl-[1 ,2,4]triazolo[4, 3-a]pyridin-6-yl)-3-methyl-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one (Step 10 of Example 3, 100 mg, 0.255 mmol)in DMF (4 mL) was added NaH (13.27 mg, 0.332 mmol) under Ar. After 30 mm at rt, 3-bromo-1- methypyrrolidin-2-one (54.5 mg, 0.306 mmol) was added. The reaction mixture stirred for 1 h at rt, quenched with a saturated aqueous solution of NaHCO3 (75 mL) and extracted with EtOAc (2 x 75 mL). The organic layers were combined, washed with a saturated aqueous solution of NaHCO3 (75 mL), dried on Na2504 and evaporated. The residue was purified by silica gelchromatography on Combiflash Isco (eluent: DCM/MeOH; gradient: 0-10% MeOH in 12 mm, 2 mm 10% MeOH; flow: 18 mL/min) and subsequent SF0 to afford 12 mg of diastereomerA and 25 mg of diastereomer B. The title compound was prepared using an analogous procedure to that described in Example 126 but using dimethylaminoethyl bromide hydrobromide (71.3 mg, 0.306 mmol, 1.2 eq) and 3eq of NaH. The crude product was purified by silica gel chromatography on Combiflash Isco (eluent: DCM/MeOH; gradient: 0-10% MeOH in 12 mm, 3.6 mm 10% MeOH; flow: 18 mL/min) and subsequent trituration of the resulting material in diethyl ether to afford (65 mg) of the title compound as a colorless solid. Rt: 0.62 mm (LC-MS 1); ESI-MS mlz: 463.2 [M+H] (LC-MS 1); 1H NMR (400 MHz, DMSO-d6) O 8.31 (d, J = 1.7 Hz, 1H), 7.42- 7.26 (m, 5H), 6.71 (5, 1H), 6.42(5, 1H), 3.72-3.57 (m, 1H), 3.57-3.44 (m, 1H), 2.59 (5, 3H), 2.41 (5, 3H), 2.29-2.18 (m, 1H),2.14 (5, 3H), 2.08- 1.91 (m, 7H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-N,N-dimethylethanamine hydrobromide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NOVARTIS AG; BLANK, Jutta; BOLD, Guido; BORDAS, Vincent; COTESTA, Simona; GUAGNANO, Vito; RUeEGER, Heinrich; VAUPEL, Andrea; WO2015/75665; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary