Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 454-65-9, name is 3-Bromobenzene-1-sulfonyl fluoride, A new synthetic method of this compound is introduced below., Recommanded Product: 454-65-9
General procedure: To a Schlenk tube equipped with a stirrer, 4-biphenylsulfonyl fluoride (23.6 mg, 0.10 mmol) was added at room temperature,Tris (trimethylsilyl) amine (70.1 mg, 0.30 mmol, 1.5 equiv.) In DMF (0.50 mL) was charged,After cooling to 0 C.,P4-tBu base (37.5 muL, 0.030 mmol, 0.30 equiv.) Was added thereto.Trifluoromethane (excess) was then bubbled through for 1 minute After that, the reaction was carried out at the same temperature for 7 hours.After completion of the reaction, a saturated ammonium chloride aqueous solution was added,The organic layer was extracted with methylene chloride, the obtained organic layer was washed with a saturated sodium chloride aqueous solution,After drying over thorium, the solvent was distilled off under reduced pressure to obtain a crude product. The obtained crude product was purified by silica gel chromatography Purification by column chromatography gave 4- (trifluoromethylsulfonyl) biphenyl (3) as a target product in a yield of 84%.
The synthetic route of 454-65-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NAGOYA INSTITUTE OF TECHNOLOGY; TOSOH F-TECH INCORPORATED; SHIBATA, NORIO; OKUSU, SATOSHI; KAGAWA, TAKUMI; (11 pag.)JP2016/204275; (2016); A;,
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