Reference of 57946-63-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 57946-63-1, name is 2-Bromo-4-(trifluoromethyl)aniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Heat a mixture of copper [(1)] cyanide (2.24g, 25.00 mmol), and 2-bromo-4- trifluoromethyl-phenylamine [(5.] [0G,] 20.83 mmol from Avocado) in [ L-METHYL-2-] pyrrolidinone (20 ml) to [195 ¡ãC] for four hours. Dilute the reaction mixture with 100 ml of ethyl acetate and wash the dark solution twice with 28percent aqueous ammonium hydroxide, twice with saturated aqueous sodium chloride (brine) and twice with water. Collect the organic layer, dry over sodium sulfate and remove the solvent under reduced pressure. Purify the residue via flash chromatography eluting with a step gradient starting with hexanes and going to 70percent hexanes with 30percent ethyl acetate to obtain 1. [821G] (9.78 mmol, 47percent yield) the title compound as a green amorphous solid: Mass Spectrum (m/e): 187 (M+1).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-4-(trifluoromethyl)aniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ELI LILLY AND COMPANY; WO2004/14895; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary