1000994-95-5, name is 1-Bromo-4-(1,1-difluoroethyl)benzene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 1000994-95-5
Nitrogen,Titration in the following -60 1.6M n-butyllithium in hexane (0.4 mL)in1-Bromo-4- (1,1-difluoroethyl) benzene(0.17 g)Of tetrahydrofuran (0.61 g)The solution was stirred for an additional 1 hour and titrated for 4 minutes5-cyclopropyl-6-methoxymethylpyridinecarbonitrile(0.10 g)In tetrahydrofuran (0.30 g).After stirring for 2 hours and 2 minutes, the temperature was further raised to room temperature.After adding 5% aqueous hydrochloric acid solution (0.93 g) and stirring,Water and ethyl acetate were added,The mixture was separated into a mixture of an organic layer and an aqueous layer.Ethyl acetate (4 mL) was added to the resulting aqueous layer,Mixed and separated into an organic layer and an aqueous layer.Mixing the organic layers of both,The mixture was separated by adding 5% aqueous sodium hydrogencarbonate solution, and the organic layer and the aqueous layer were mixed.Ethyl acetate (2 mL) was added to the resulting aqueous layer,Mixed and separated into an organic layer and an aqueous layer.The organic layers were mixed, and the organic layer and the aqueous layer were mixed by adding water. Ethyl acetate (2 mL) was added to the obtained aqueous layer, mixed, and separated into an organic layer and an aqueous layer. The organic layers were mixed, dried by addition of sodium sulfate, and after the desiccant was filtered off, the solvent was distilled off under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexane / ethyl acetate = 49/1, v / v)To obtain the title compound (0.14 g, yield 75.1%) as a pale yellow oily substance.
The synthetic route of 1000994-95-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NISSAN CHEMICAL INDUSTRIES, LTD.; YOSHINO, HIRONOBU; UMEDA, YASUHIRO; TAKEOKA, JUN; NAGAYA, AKIHIRO; SUGAWARA, YUDAI; YOSHINO, MADOKA; (54 pag.)TW2016/5826; (2016); A;,
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