Some common heterocyclic compound, 4117-09-3, name is 7-Bromo-1-heptene, molecular formula is C7H13Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 7-Bromo-1-heptene
To a solution of methyl isobutyrate (2g; 19.60 mmol) in 25ml of THF at -78C was added lithium diisopropylamide (2.0M, 1.2 equiv; 11.77ml) dropwise. After 30 minutes, a solution of 7-bromo-1-heptene (1.2 equiv; 4.14g) in 5ml of THF was added slowly. The reaction was stirred at room temperature for 1-2 hours (until TLC showed completion), then it was diluted with ether and washed with 1M HCl, then water and finally brine. It was dried over sodium sulfate and purified on silica gel (5% ethyl acetate/hexane) to yield 3.25g (87%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4117-09-3, its application will become more common.
Reference:
Patent; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES; KEYES, Gregory; RAMSDEN, Christopher; (158 pag.)WO2019/10414; (2019); A1;,
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