Application of 30273-40-6,Some common heterocyclic compound, 30273-40-6, name is 4-Bromo-2,5-dimethylaniline, molecular formula is C8H10BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation example 1 – Process (a) – compound (Na) to compound (VII) : 4′-tert-butyl-2,5- diotamethylbiotaphenyl-4-amiotane – intermediate (VII-P; The reaction is carried out using inert conditions (argon or nitrogen atmosphere, dry solvents). A suspension of 6.4 g (36.0 mmol) of (4-tert-butylphenyl)boroniotac acid, 6.0 g (30.0 mmol) of 4- bromo-2,5-diotamethylaniotaliotane, 29.3 g (90 mmol) caesium carbonate and 0.7 g (0.6 mmol) tetrakiotas(triotaphenylphosphiotan)palladiotaum in 75 ml of 1 ,2-diotamethoxyethan was stirred for 16 hrs at8O0C. At room temperature 25 ml of water and 75 ml of toluene were added. The organic layer was separated, the watery layer was again extracted using 75 ml of toluene. The combined organic layers were dried over magnesium sulfate and concentrated in vacuo. Column chromatographie (cyclohexane / ethylacetate : 2/1 ) yielded 5.5g (21 ,7 mmol) 72 % of 4′-tert- butyl-2,5-diotamethylbiotaphenyl-4-amiotane (log P (pH 2.3) = 3.65.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-2,5-dimethylaniline, its application will become more common.
Reference:
Patent; BAYER CROPSCIENCE AG; WO2007/31512; (2007); A2;,
Bromide – Wikipedia,
bromide – Wiktionary