Continuously updated synthesis method about 73918-56-6

The synthetic route of 73918-56-6 has been constantly updated, and we look forward to future research findings.

73918-56-6, name is 2-(4-Bromophenyl)ethanamine, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 2-(4-Bromophenyl)ethanamine

Preparation of N-(4-bromophenethyl)-2,2,2-trifluoroacetamide:; To a solution of 2-(4-bromophenyl)ethanamine (10 g, 50 mmol) and NEt3 (13.9 mL, 100 mmol) in 50 mL of dry THF at room temperature was slowly added TFAA (7.76 mL, 55 mmol). After stirring at room temperature for 1 h, the reaction mixture was quenched with Sat. NaHCO3 solution, extracted with EtOAc, washed with brine, dried over Na2SO4, and evaporated in vaco to give N-(4-bromophenethyl)-2,2,2-trifluoroacetamide as a white solid.

The synthetic route of 73918-56-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Askew, Benny C.; Aya, Toshihiro; Biswas, Kaustav; Cai, Guolin; Chen, Jian J.; Han, Nianhe; Liu, Qingyian; Nguyen, Thomas; Nishimura, Nobuko; Nomak, Rana; Peterkin, Tanya; Qian, Wenyuan; Yang, Kevin; Yuan, Chester Chenguang; Zhu, Jiawang; D’ Amico, Derin C.; Human, Jason B.; Huang, Qi; US2006/25400; (2006); A1;,
Bromide – Wikipedia,
bromide – Wiktionary