These common heterocyclic compound, 1422-53-3, name is 2-Bromo-4-fluorotoluene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C7H6BrF
Reference Example 3 Production of 5-fluoro-2-methylbenzaldehyde: Iodine (about 1 mg) was added to a mixture of magnesium (26.28 g) and tetrahydrofuran (600 ml) and 2-bromo-4-fluorotoluene (200.4 g) was added dropwise thereto with ice-cooling (the inner temperature was kept at 65C or lower). After completion of the dropwise addition, the mixture was stirred for 1 hour to prepare a Grignard reagent.
The synthetic route of 2-Bromo-4-fluorotoluene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1229019; (2002); A1;,
Bromide – Wikipedia,
bromide – Wiktionary