Electric Literature of 103273-01-4, These common heterocyclic compound, 103273-01-4, name is 2-Bromo-4-(tert-butyl)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
99.7 g (0.437 mol) of Intermediate 41 and 997 ml of tetrahydrofuran were added. 100.2 g (0.454 mol) of Intermediate 122 was dissolved in 506 ml of tetrahydrofuran and then, was slowly added thereto, followed by stirring for about 2 hours. After finishing the reaction, solvents were removed by distillation under a reduced pressure. The resultant product was extracted using EA and a sodium carbonate aqueous solution, and water was removed with MgSO4. Solvents were removed by distillation under a reduced pressure, and the resultant product was solidified to obtain 155.6 g (86.4%) of ivory Intermediate 123.
The synthetic route of 103273-01-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SAMSUNG DISPLAY CO., LTD.; LAPTO CO., LTD.; BAE, Sung-soo; CHO, Hwanhee; OH, Eu-gene; JEONG, Hyein; KIM, Gyuri; HAN, Kap-jong; KIM, Namho; KIM, Hyejeong; MAENG, Juwan; PARK, Yongpil; YOON, Jeunghun; (531 pag.)US2019/181358; (2019); A1;,
Bromide – Wikipedia,
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