In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 40161-54-4 as follows. SDS of cas: 40161-54-4
To a mixture of 1-bromo-2-fluoro-4- (trifluoromethyl) benzene (5.0 g, 0.02 mol) in EtOH (10 mL) was added Pd (dppf) Cl2 (1.46 g, 0.2 mmol ) and AcONa (3.37 g, 0.041 mol) , and the resulting mixture was stirred at 80under an atmosphere of CO (50 psi) for 8 hours. The mixture was then filtrated and the filtrate was partitioned with ethyl acetate and water. The aqueous layer was separated and extracted with ethyl acetate twice. The combined organic layers were washed with brine, dried over anhydrous Na2SO4 and concentrated in vacuo. The resulting residue was purified by column chromatography on silica gel (eluting with PE:EA10:1) to give the title compound. 1H NMR (400MHz, CDCl3) delta: 8.04-8.08 (t, 1H, J7.6 Hz) , 7.49-7.47 (d, 1H, J8.0 Hz) , 7.43-7.40 (d, 1H, J10.4 Hz) , 4.44-4.40 (q, 2H, J7.2 Hz) , 1.43-1.38 (t, 3H, J7.2Hz) .
According to the analysis of related databases, 40161-54-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; BIFTU, Tesfaye; BIJU, Purakkatle; COLLETTI, Steven L.; CUI, Mingxiang; HAGMANN, William K.; HU, Bin; JOSIEN, Hubert; KAR, Nam Fung; NAIR, Anilkumar; NARGUND, Ravi; SPERBECK, Donald M.; ZHU, Chen; WO2015/51725; (2015); A1;,
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