18648-66-3, name is 2-(4-Bromophenyl)-1,1-diphenylethylene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 18648-66-3
General procedure: A flask was charged with a mixture of 3-(4-vinylphenyl)-9-ethylcarbazole (1, 0.3 g, 1.01 mmol), 2-(4-bromophenyl)-1,1-diphenylethylene (triPE, 0.28 g, 0.84 mmol), palladium acetate(Pd(OAc)2, 2.3 mg, 0.01 mmol), P(o-tolyl)3 (15 mg, 0.05 mmol),dimethylformamide (8 mL) and trimethylamine (3 mL). The flaskwas degassed and purged with argon. The reaction mixture washeated at 90 C for 4 h under argon atmosphere. Then, it wasfiltered, and was purified by column chromatography using hexane/ethyl acetate (50/1) as an eluent. The target product wasrecrystallized from the eluent mixture of solvents. The yield ofyellow crystals was 43% (0.2 g).
The synthetic route of 18648-66-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Tomkeviciene; Sutaite; Volyniuk; Kostiv; Simkus; Mimaite; Grazulevicius; Dyes and Pigments; vol. 140; (2017); p. 363 – 374;,
Bromide – Wikipedia,
bromide – Wiktionary