Adding a certain compound to certain chemical reactions, such as: 1422-54-4, name is 2-Bromo-6-fluorotoluene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1422-54-4, HPLC of Formula: C7H6BrF
Sodium benzyloxide was prepared by adding benzyl alcohol (20 mmol) to a suspension of NaH (20 mmol) in N-methylpyrrolidone . The freshly prepared solution (10.8 mmol) was added to 1- bromo-3-fluoro-2-methylbenzene (5.41 mmol) in N methylpyrrolidone . The reaction was heated at 100 C and was monitored by TLC until complete consumption of the starting material. Water and ethyl acetate were added, the aqueous layer was separated and the organic layer was washed with water, dried over MgS04, filtered and concentrated. The residue was chromatographed with hexane/EtOAc mixture. Yield: 92%. 1H NMR (500 MHz, CDC13) delta 7.49-7.39 (m, 4H) , 7.37 (d, J = 7.0 Hz, 1H) , 7.20 (d, J = 8.0 Hz, 1H) , 7.02 (t, J = 8.1 Hz, 1H) , 6.86 (d, J = 8.2 Hz, 1H) , 5.09 (s, 2H) , 2.41 (d, J = 3.3 Hz, 3H) . 13C NMR (126 MHz, CDC13) delta 157.5, 137.0, 128.6, 128.0, 127.3, 127.3, 127.2, 126.0, 125.0, 110.7, 70.5, 16.0. MS (EI) m/z 277 (M+) .
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Reference:
Patent; RIJKSUNIVERSITEIT GRONINGEN; DOeMLING, Alexander; (85 pag.)WO2017/118762; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary