Adding a certain compound to certain chemical reactions, such as: 129316-09-2, name is 1,3-Dibromo-5-(tert-butyl)benzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 129316-09-2, Formula: C10H12Br2
Step 1 : 3-(3-bromo-5-(teit-butyl)ohenvnoxetan-3-ol (P29a)To a solution of 1 ,3-dibromo-5-(terf-butyl)benzene (316 mg, 1.05 mmol) in dry THF (15 mL), n- BuLi (1 mL, 2.5M) was added dropwise under N2 at -78C. The mixture was stirred at this temperature for 1h. Then oxetan-3-one (91 mg, 1.27 mmol) was added and the mixture was stirred at rt overnight, diluted with aq. NH4CI (20 mL) and extracted with EA. The combined organic layers were washed with brine, dried over Na2S04 and concentrated to give the product P29a (120 mg, 40%) as a yellow solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3-Dibromo-5-(tert-butyl)benzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; KINZEL, Olaf; GEGE, Christian; KLEYMANN, Gerald; HOFFMANN, Thomas; WO2012/139775; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary