Adding a certain compound to certain chemical reactions, such as: 1073-39-8, name is 3-Bromobicyclo[4.2.0]octa-1,3,5-triene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1073-39-8, Quality Control of 3-Bromobicyclo[4.2.0]octa-1,3,5-triene
To a mixture of 3-bromobicyclo[4.2.0]octa-1 (6),2,4-triene (300 mg, 1.64 mmol, 1.10 equiv) in THF (4 mL) was added n-BuLi (2.5 M in hexane, 0.66 mL, 1.64 mmol, 1.00 equiv) dropwise at -78C. The reaction mixture was stirred for 30 min at -78C. To the resulting mixture was then added a solution of 4- (benzyloxy)-5-bromo-2-(dimethylamino)benzaldehyde (500 mg, 1.50 mmol, 1.00 equiv) in THF (1 mL) dropwise at -78 C. The reaction mixture was stirred for 3 h at -78C. NH4CI/H2O was added and the mixture was extracted with EtOAc thrice. The combined extracts were washed with brine and dried over Na2S04, then concentrated and purified by chromatography on silica gel (3: 1 PE/EA) to yield (4-(benzyloxy)-5-bromo-2-(dimethylamino)phenyl)(1,2- dihydrocyclobutabenzen-4-yl)methanol as a colorless oil.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Bromobicyclo[4.2.0]octa-1,3,5-triene, and friends who are interested can also refer to it.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; GAUL, Micheal; KUO, Gee-Hong; XU, Guozhang; LIANG, Yin; (218 pag.)WO2018/89449; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary