Some common heterocyclic compound, 64248-56-2, name is 2-Bromo-1,3-difluorobenzene, molecular formula is C6H3BrF2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C6H3BrF2
A solution of 2-bromo-1,3-difluorobenzene (25.0 g, 130 mmol) in concentrated H2SO4 (52 mL, 98%) was vigorously stirred at room temperature. Then, concentrated nitric acid (9 mL, 70%) was added dropwise to the solution, and the internal temperature was maintained to be lower than 55C. After the addition, the mixture was further stirred for 30 minutes, and poured on ice. CH2Cl2 (200 mL x 2) was added to the mixture for extraction of the desired compound. The combined organic layer was washed with saturated Na2CO3 and brine, dried over Na2SO4, and concentrated to give 2-bromo-1,3-difluoro-4-nitrobenzene as yellow solid (23.0 g, yield 74%). 1H-NMR Spectrum (300MHz, CDCl3):delta (ppm): 7.10-7.16 (m, 1H), 8.09-8.16 (m, 1H)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 64248-56-2, its application will become more common.
Reference:
Patent; Juntendo Educational Foundation; HIRAMATSU Keiichi; MORIMOTO Yuh; BABA Tadashi; HAYAKAWA Isao; (76 pag.)EP2987787; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary