Related Products of 202865-83-6, The chemical industry reduces the impact on the environment during synthesis 202865-83-6, name is 1-Bromo-3-fluoro-5-methylbenzene, I believe this compound will play a more active role in future production and life.
Compound 22b (50 mg, 177.09 mumol), 1-bromo-3-fluoro-5-methylbenzene (46.87 mg, 247.93 mumol), Pd (OAc) 2 (7.9 mg, 0.035 mmol), BINAP (44 mg, 0.071 mmol) ) And Cs2CO3 (145mg, 0.442mmol) were added in 5mL toluene, heated to 90 under N2 protection for 5h. After the reaction was completed, it was filtered through celite, and the filtrate was spin-dried and separated and purified by a preparative silica gel plate (eluent system B) to obtain compound 22c (10 mg).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-3-fluoro-5-methylbenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Li Guiying; Sun Xiaoyang; You Zejin; Cai Jiaqiang; Wang Lichun; Wang Jingyi; (55 pag.)CN110857298; (2020); A;,
Bromide – Wikipedia,
bromide – Wiktionary