Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 399-94-0, name is 1-Bromo-2,5-difluorobenzene, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H3BrF2
2,5-Difluorobromobenzene (500 mg, 2.6 mmol) was dissolved in 5 mL of THF.An isopropylmagnesium chloride anhydrous THF solution (1.56 mL, 3.12 mmol) was slowly added dropwise at -45 C.After the dropwise addition, the temperature was naturally raised to 0 C and stirred for 1 h.Further, a solution of Compound 17 (466 mg, 2.46 mmol) in tetrahydrofuran (5 mL) was slowly added dropwise at -15 C, and stirred at room temperature for 30 min.The reaction solution was poured into 10 mL of a saturated ammonium chloride solution and stirred for 10 min.The mixture was separated and the aqueous phase was extracted three times with 10 mL of ethyl acetate.The combined organic layers were washed with brine and dried over anhydrous sodium sulfate. Concentration by filtration, column chromatography (PE / EA, 0% ~ 10%) to give 367 mg of colorless solids as compound 18Yield: 46.6%.
The synthetic route of 399-94-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.; Wang Yihan; Zhao Jiuyang; (32 pag.)CN109456331; (2019); A;,
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bromide – Wiktionary