Adding a certain compound to certain chemical reactions, such as: 3638-73-1, name is 2,5-Dibromoaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3638-73-1, Recommanded Product: 3638-73-1
A synthetic scheme for Amino UiO-68 is shown in Figure 15. Briefly, 2,5-dibromoaniline (2.00 g, 8.0 mmol), 4-(methoxycarbonyl)-phenylboronic acid (4.40 g, 24.5 mmol) and CsF (5.82 g, 38 mmol) were suspended in 50 mL of anhydrous tetrahydrofuran (THF) under nitrogen protection in a 100 mL round-bottom flask. Pd(OAc)2 (0.60 g, 2.7 mmol) and PPh3 (1 .61 g, 6.1 mmol) were then added. The mixture was heated at 50C for 48 h. The product was purified by water/dichloromethane extraction and silica gel column chromatography (dichloromethane: ethyl ether = 50:1 with 0.2% – 0.5% triethylamine). Yield: 58%. H NMR (Chloroform-D): delta=8.10 (m, 4H), 7.65 (d, 2H), 7.57 (d, 2H), 7.22 (d, 1 H), 7.09 (d, 1 H), 7.01 (s, 1 H), 3.93 (two overlapping singlets, 6H), 3.88 (s, 2H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,5-Dibromoaniline, and friends who are interested can also refer to it.
Reference:
Patent; THE UNIVERSITY OF CHICAGO; LIN, Wenbin; HE, Chunbai; LU, Kuangda; (166 pag.)WO2016/61256; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary