Reference of 4117-09-3, The chemical industry reduces the impact on the environment during synthesis 4117-09-3, name is 7-Bromo-1-heptene, I believe this compound will play a more active role in future production and life.
To a mixture of 0.20 g of N-benzothiazol-6-yl-2-(2-fluoro-3-hydroxy- phenyl)acetamide, 0.25 g of 7-bromo-l-heptene and 3ml of DMF was added 0.46 g of cesium carbonate. The mixture was stirred at room temperature for 4 hours. Ice water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated saline solution, then, dried over magnesium sulfate and concentrated under reduced pressure. The resultant residue was subjected to silica gel column chromatography, and 0.16 g of N-benzothiazol-6-yl-2-(3 -(6-hepteny loxy)phenyl)acetamide (hereinafter, referred to as the present compound (17)) was obtained. The present compound (17)1H-NMR (CDCl3)delta: 1.45-1.52 (4H, m), 1.77-1.84 (2H, m), 2.05-2.13 (2H5 m), 3.75 (2H5 s), 3.97 (2H5 1, J = 6.5 Hz)5 4.93-5.03 (2H, m), 5.76-5.86 (IH5 m),6.87-6.95 (3H5 m), 7.18 (IH5 dd, J = 8.8, 2.0 Hz), 7.28-7.36 (2H, m), 7.99 (IH, d, J = 8.8 Hz)5 8.49 (IH, d, J = 2.0 Hz)5 8.90 (IH5 s).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Bromo-1-heptene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; SAKAGUCHI, Hiroshi; WO2010/24422; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary