Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10546-67-5, name is 2,6-Dibromo-4-(tert-butyl)aniline, A new synthetic method of this compound is introduced below., Formula: C10H13Br2N
To a stirring solution of 2,6-dibromo-4-tert-butylaniline in 115 mL of EtOH was added 11.5 mL of concentrated H2SO4. To the stirring solution at 90 0C was added 8.8 g of NaNO2 in several portions. After 37 h, EtOAc and 120 mL of H2O were added, and the layers separated. The organic layer was washed with 40 mL of brine, dried over Na2SO4, filtered, and concentrated. Purification by flash silica gel chromatography (hexanes) provided 8.15 g of l,3-dibromo-5-tert-butylbenzene as a yellow-brown oil with some impurity.
The synthetic route of 10546-67-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; COMENTIS, INC.; PURDUE RESEARCH FOUNDATION; WO2009/42694; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary