Application of 454-79-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 454-79-5 name is 2-Bromo-5-(trifluoromethyl)aniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Add 2-bromo-5-trifluoromethyl-aniline (10 mmol) to a reaction vessel containing 25 ml of glacial acetic acid.3-methylfuryl-2,5-dione (11 mmol) was added,The mixture was refluxed overnight and then cooled to <50 C.The solvent was transferred in vacuo, the residue was dissolved in dichloromethane (50 ml), and the resulting solution was washed with water (50 ml x 2), saturated aqueous NaHCO3 (50 ml x 2) and saturated brine (50 ml x 2), and anhydrous Dry over sodium sulfate. Evaporate the solvent in vacuumThe residue was dissolved in 15 ml of acetone, and then crystallized by dropwise addition of 30 ml of ethanol, filtered, and vacuum dried at 50C to obtain 2.9 g of white 1-(2-bromo-5-trifluoromethyl-phenyl)-3-methyl- 1H-pyrrole-2,5-dione solid, yield 87%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-5-(trifluoromethyl)aniline, and friends who are interested can also refer to it.
Reference:
Patent; Tian Yuanqiang; (10 pag.)CN107954992; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary