Adding a certain compound to certain chemical reactions, such as: 454-79-5, name is 2-Bromo-5-(trifluoromethyl)aniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 454-79-5, name: 2-Bromo-5-(trifluoromethyl)aniline
2-Bromo-5-(trifluoromethyl)aniline (2.0 g, 8.3 mmol),4-(pinacol ester-2-yl)-5,6-dihydropyridine-1(2H)-carboxylic acid tert-butyl ester (3.1 g, 10 mmol),Potassium acetate (1.23 g, 12.5 mmol) and [1,1′-bis(diphenylphosphino)ferrocene]palladium dichloride (343 mg, 0.42 mmol) were added to N,N-dimethylformamide ( Mix of 30mL) and water (2mL)In the solvent, the reaction was heated to 90 C for 16 hours under a nitrogen atmosphere. The reaction was quenched and cooled to room temperature. The mixture was poured into water (100 mL), dichloromethane (30 mL¡Á3) (Dichloromethane: methanol (V: V) = 50: 1) isolated and purified to give the title compound(Yellow solid, 2.42 g, 85%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-5-(trifluoromethyl)aniline, and friends who are interested can also refer to it.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jin Chuanfei; Zhang Yingjun; Xue Yaping; Guo Zhengjiang; (39 pag.)CN109912514; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary