Synthetic Route of 112734-22-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 112734-22-2 name is (4-Bromo-2-fluorophenyl)methanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
3.2.1. Preparation of N-(4-bromo-2-fluorobenzyl)-4-(tert-butyl)benzamide (935-2) To a stirred solution of (4-bromo-2-fluorophenyl)methanamine (1.02 g, 5 mmol) and 4-(tert-butyl)benzoic acid (980 mg, 5.5 mmol) in DCM (10 mL) were added DIPEA (2.8 mL, 15 mmol) and (2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate) (HBTU) (2.84 g, 7.5 mmol). After being stirred at room temperature overnight, the reaction mixture was cooled down to room temperature and quenched with saturated NaHCO3. The layers were separated and the organic layer was washed with brine, dried over Na2SO4. Solvent was removed and the residue was purified by flash chromatography (silica gel, 0?20 ethyl acetate in petroleum ether) to provide N-(4-bromo-2-fluorobenzyl)-4-(tert-butyl)benzamide (935-2) (1.6 g, 88%) as a yellow oil. LC-MS (ESI): m/z (M/M+2) 364.43/366.44.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (4-Bromo-2-fluorophenyl)methanamine, and friends who are interested can also refer to it.
Reference:
Patent; Pharmacyclics LLC; Atallah, Gordana B.; Chen, Wei; Khrakovsky, Dimitry; Wang, Longcheng; Jia, Zhaozhong Jon; DeAnda, JR., Felix; (312 pag.)US2018/194762; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary