Adding a certain compound to certain chemical reactions, such as: 112279-72-8, name is 4-Bromo-2,3-difluoroaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 112279-72-8, category: bromides-buliding-blocks
Step 1 : To a solution of 4-bromo-2,3-difluoroaniline (7.66 g, 36.8 mmol) in acetone (60 mL) was dropped under ice-cooling benzoyl isothiocyanate (9.02 g, 55.2 mmol). The mixture was stirred at rt for 18 h. The precipitate was collected by filtration and washed with hexane. The obtained product was dried under reduced pressure to give A/-((4-bromo-2,3- difluorophenyl)carbamothioyl)benzamide lnt-6a-2
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Reference:
Patent; GILEAD SCIENCES, INC.; KINZEL, Olaf; KREMOSER, Claus; SCHMITT, Aaron C.; GEGE, Christian; (205 pag.)WO2016/96115; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary