Application of 126930-72-1,Some common heterocyclic compound, 126930-72-1, name is 1-Bromo-4-dodecylbenzene, molecular formula is C18H29Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(0236) To a suspension of 1-bromo-4-dodecylbenzene (2.2 g, 6.8 mmol) in anhydrous tetrahydrofuran (50 cm3) at -78 C. was added dropwise tert-butyllithium (7.2 cm3, 14 mmol, 1.9 M in pentane) over 30 minutes. After addition, the reaction mixture was stirred at -78 C. for 1 hour. 5,5?-Bis-triisopropylsilanyl-[2,2?;5?,2?]ter[thieno[3,2-b]thiophene]-3?,6?-dicarboxylic acid diethyl ester 3 (1.0 g, 1.1 mmol) was then added in one portion. The reaction mixture was then stirred at -78 C. for 2 hours and at 23 C. for 17 hours. The reaction mixture was poured into water (150 cm3) and the organics extracted with diethyl ether (5¡Á50 cm3). The combined organics were washed with brine (100 cm3), dried over anhydrous magnesium sulphate, filtered and the solvent removed in vacuo. The crude was purified by column chromatography (n-pentane) to give {6?[bis-(4-dodecyl-phenyl)-hydroxy-methyl]-5,5?-bis-triisopropylsilanyl-[2,2?;5?,2?]ter[thieno[3,2-b]thiophene]-3?-yl}-bis-(4-dodecyl-phenyl)-methanol 4 (800 mg, 40%) as a colourless oil. (0237) 1H-NMR (300 MHz, CDCl3) 0.84-0.92 (12H, m), 1.06-1.17 (36H, m), 1.21-1.37 (78H, m), 1.54-1.66 (8H, m), 2.53-2.63 (8H, m), 3.45 (2H, s), 6.50 (2H, s), 7.08 (8H, d, J 8.3), 7.17 (2H, s), 7.20 (8H, d, J 8.3)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-4-dodecylbenzene, its application will become more common.
Reference:
Patent; MERCK PATENT GMBH; MITCHELL, William; D’LAVARI, Mansoor; WANG, Changsheng; SPARROWE, David; (45 pag.)US2016/301008; (2016); A1;,
Bromide – Wikipedia,
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