Related Products of 2862-39-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2862-39-7, name is 2-Bromo-N,N-dimethylethanamine hydrobromide, This compound has unique chemical properties. The synthetic route is as follows.
A stirred mixture of 3,3-bis(4-hydroxyphenyl)-2-(thiophen-2-yl)acrylonitrile (11; 30 mg, 0.1 mmol), 2-bromo-N,N-dimethylethylamine hydrobromide (328 mg, 1.4 mmol), cesium carbonate (612 mg, 1.9 mmol), and acetonitrile (3 mL) was heated at reflux for 18 h. The mixture was diluted with water and extracted with ethyl acetate (3x). The combined extracts were washed successively with water and sat. brine, dried and concentrated to a syrup that was purified by flash silica gel chromatography, eluting first with 4-5 column volumes of 3:1 dichloromethane/methanol and then with 95:5 methanol/conc. ammonium hydroxide to elute the product. Combined product fractions were concentrated to leave 12 (18 mg, 42%) as an amber gum. HPLC: rt 5.1 min (89% purity). 1H NMR (400 MHz, DMSO-d6): delta 7.46 (d, J = 5.2 Hz, 1H), 7.32 (d, J = 8.9 Hz, 2H), 7.17 (d, J = 2.5 Hz, 1H), 7.08 (d, J = 8.8 Hz, 2H), 7.03-6.87 (m, 5H), 4.15-3.97 (m, 4H), 2.65-2.53 (m, 4H), 2.20 (s, 12H). MS TOFES+: m/z 462.1 (M+H)+.
The chemical industry reduces the impact on the environment during synthesis 2-Bromo-N,N-dimethylethanamine hydrobromide. I believe this compound will play a more active role in future production and life.
Reference:
Article; Carpenter, Colleen; Sorenson, Roderick J.; Jin, Yafei; Klossowski, Szymon; Cierpicki, Tomasz; Gnegy, Margaret; Showalter, Hollis D.; Bioorganic and Medicinal Chemistry; vol. 24; 21; (2016); p. 5495 – 5504;,
Bromide – Wikipedia,
bromide – Wiktionary