Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3875-78-3, name is 6-Bromochroman, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 3875-78-3
To a mixture of 6-bromochromane (2.0 g, 9.43 mmol, 1.00 equiv) in THF (20 ml_) was added n-BuLi (2.5 M in hexane, 3.76 ml_, 1.00 equiv) dropwise at – 78C. The reaction mixture was stirred at -78C for 30 min. To the mixture was then added a solution of 4-(benzyloxy)-5-bromo-2-methoxybenzaldehyde (2.74 g, 8.56 mmol, 0.91 equiv) in THF (2 ml_) dropwise at -78C. The reaction mixture was stirred for 2 h at -78C. NH4CI/H2O was added and the mixture was extracted with EtOAc thrice. The combined extracts were washed with brine and dried over Na2SC>4. The mixture was concentrated and the resulting residue purified by chromatography on silica gel (3: 1 PE/EA) to yield (4-(benzyloxy)-5-bromo-2-methoxyphenyl)(chroman-6-yl)methanol as a colorless oil.
According to the analysis of related databases, 3875-78-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; GUOZHANG, Xu; KUO, Gee-Hong; GAUL, Micheal; (163 pag.)WO2019/215633; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary