Related Products of 1435-52-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1435-52-5, name is 1,4-Dibromo-2-fluorobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: 6.12 1,4-Di(3′-chlorophenyl)-4-fluorobenzene (7l): Starting with 6 (200 mg, 0.79 mmol), Cs2CO3 (385 mg, 1.81 mmol), Pd(PPh3)4 (3 molpercent), 3-chlorophenylboronic acid (246 mg, 1.58 mmol) and 1,4-dioxane (4 mL), 7l was isolated as a colorless solid (201 mg, 80percent). Mp 102-103 ¡ãC. 1H NMR (300 MHz, CDCl3): delta = 7.25-7.33 (m, 5H, ArH), 7.34-7.35 (m, 1H, ArH). 7.37-7.43 (m, 3H, ArH), 7.49-7.52 (m, 2H, ArH). 13C NMR (75 MHz, CDCl3): delta = 114.8 (d, J = 25.7 Hz, CH), 123.0 (d, J = 4.0 Hz, CH), 125.1 (CH), 127.1 (2CH), 128.0 (d, J = 9.4 Hz, 2CH), 129.0 (d, J = 4.0 Hz, CH), 130.0 (d, J = 33.7 Hz, 2CH), 131.0 (d, J = 4.0 Hz, CH), 134.4 (C), 134.9 (C), 137.0 (C), 141.1 (C), 141.4 (C), 141.5 (C), 159.9 (d, JCF = 248.8 Hz, CF). 19F NMR (282 MHz, CDCl3): delta = -114.6 (CF). IR (ATR, cm-1): , 2923 (w), 2851 (w), 1619 (m), 1562 (m), 1463 (m), 1386 (s), 1288 (m), 1248 (m), 1186 (m), 1130 (m), 1079 (m), 1022 (m), 967 (m), 915 (m), 876 (m), 824 (m), 773 (s), 756 (s), 686 (s), 636 (m), 552 (m), 515 (m), 468 (m), 419 (m) cm-1. GC-MS (EI, 70 eV): m/z (percent) = 292 (100) [M]+, 277 (34), 249 (23), 233 (12). HRMS (EI) calcd. for C18H11Cl2F [M]+: 316.02164; found 316.021941; calcd. for C18H11Cl37ClF [M]+: 318.01869; found 318.01898.
The synthetic route of 1,4-Dibromo-2-fluorobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Article; Sharif, Muhammad; Maalik, Aneela; Reimann, Sebastian; Feist, Holger; Iqbal, Jamshed; Patonay, Tama?s; Villinger, Alexander; Langer, Peter; Journal of Fluorine Chemistry; vol. 146; (2013); p. 19 – 36;,
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