In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 59907-13-0, name is 2-Bromo-1-fluoro-3-methylbenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C7H6BrF
General procedure: To a mixture of the appropriate amine F-1 (1 eq), the appropriate halide (1.2 eq) and sodium tert-butoxide (2 eq) in toluene (3 mL/mmol) under N2, was added BINAP (0.2 eq) and Pd2(dba)3 (0.1 eq) (see Table 4). The rxn mixture was flushed with N2, heated to 100C in a sealed vial and stirred for 24h. It was partitioned between water and EtOAc and the org. phase was washed with brine, dried over MgS04 and concentrated in vacuo. The crude was purified by CC using Hept/EtOAc.
The synthetic route of 59907-13-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; IDORSIA PHARMACEUTICALS LTD; FROIDEVAUX, Sylvie; HUBLER, Francis; MURPHY, Mark; RENNEBERG, Dorte; STAMM, Simon; (97 pag.)WO2019/141808; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary