Adding a certain compound to certain chemical reactions, such as: 51554-93-9, name is 1-Bromo-4-octylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 51554-93-9, Quality Control of 1-Bromo-4-octylbenzene
a) Synthesis of 4-bromophenyl 1-pinacolylboronate 50.0 g (186 mmol) of 4-n-octyl bromide, 51.9 g (204 mmol) of bispinacolatodiboron, 52.9 g (539 mmol) of potassium acetate are suspended in 800 ml of dimethyl sulfoxide. 4.55 g (5.6 mmol) of 1,1-bis(diphenylphosphino)ferrocenedichloropalladium(II)*DCM are added to this suspension, and the reaction mixture is heated under reflux for 16 h. After cooling, 600 ml of ethyl acetate and 400 ml of water are added, and the organic phase is separated off, washed three times with 200 ml of water, dried using sodium sulfate and subsequently evaporated to dryness. The crude product is recrystallised from heptane and finally dried under reduced pressure. The yield is 48.2 g (152 mmol), corresponding to 82.0% of theory.
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Reference:
Patent; Merck Patent GmbH; Buchholz, Herwig; Pan, Junyou; Anemian, Remi Manouk; (27 pag.)US9822299; (2017); B2;,
Bromide – Wikipedia,
bromide – Wiktionary