Reference of 7073-94-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7073-94-1 name is 1-Bromo-2-isopropylbenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Add 4.8 mmol (117 mg) of magnesium metal to a 25 mL Shrek bottle, 10 mL of tetrahydrofuran and 4 mmol (0.62 mL) of 2-isopropylbromobenzene, Stir at room temperature for 1h, Let stand. In a 250 mL three-necked flask, add 0.4 mmol (232 mg) of the compound represented by formula (XIa) and 80 mL of tetrahydrofuran. Cool to -20 , The fresh Grignard reagent was transferred to a 25 mL constant pressure dropping funnel and slowly added to the reaction system. After the dropping was completed, the system was transferred to room temperature and the reaction was continued for 12 h. After the reaction was completed, a saturated ammonium chloride solution was added to quench it. Extract the aqueous phase with ethyl acetate, The organic phases were combined, washed with a saturated sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was spin-dried column chromatography (silica gel 100-200 mesh, eluent: dichloromethane / ethyl acetate = 10/1 to 8/1) to obtain 186 mg of the compound represented by formula (IIIc) in a yield of 44%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-2-isopropylbenzene, and friends who are interested can also refer to it.
Reference:
Patent; Tsinghua University; Wang Meixiang; Shi Tanhao; Guo Qinghui; Tong Shuo; (35 pag.)CN110372468; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary