Related Products of 698-00-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 698-00-0, name is 2-Bromo-N,N-dimethylaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 1512-{4-[4-(2-methoxyphenyl)piperazin- I -yI]-1 H-pyrazolo[3,4-d]pyrimidin- I -yI}-N,Ndimethylaniline 80 mg (0.26 mmo[) 4-[4-(2-methoxypheny[)piperazin-1 -y[]-1 H-pyrazo[o[3,4-d]pyrimidine, 77.4 mg (0.39 mmo[) 2-bromo-N,N-dimethy[ani[ine, 14.7 mg (0.08mmo[) copper(I) iodide, 115 mg (0.54 mmo[) tripotassium phosphate and 22mg (0.16mmo[) trans-N,N?-dimethy[cyc[ohexane-1,2-diamine in 3 mL anhydrous NMP wereheated under microwave irradiation at 180CC for 8 h. The reaction mixture waspoured into water and extracted three times with ethy[ acetate. The combinedorganic phases were washed with 0.5 M aqueous EDTA so[ution and three times with water, dried over magnesium su[fate and concentrated. The residue was purified by HPLC affording 3 mg (3%) product.LC-MS (ana[ytica[ method 3): R = 1 .09 mm, MS (ESipos): mlz = 430 (M+H).1H-NMR (300MHz, CHLOROFORM-d): 6 [ppm]= 2.52 (5, 6H), 3.25 – 3.33 (m, 4H), 3.96 (5, 3H), 4.22 – 4.30 (m, 4H), 6.92 – 7.16 (m, 6H), 7.31 (d, 1H), 7.36 – 7.45 (m, 1H), 8.25 (5, 1H), 8.45 (5, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-N,N-dimethylaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HEISLER, Iring; MUeLLER, Thomas; GOLZ, Stefan; TELSER, Joachim; REHWINKEL, Hartmut; SIEBENEICHER, Holger; BUCHMANN, Bernd; ZORN, Ludwig; EIS, Knut; KOPPITZ, Marcus; LINDNER, Niels; HEROULT, Melanie; NEUHAUS, Roland; WO2013/182612; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary