New downstream synthetic route of 1198171-18-4

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-2-(difluoromethyl)-4-fluorobenzene, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 1198171-18-4, name is 1-Bromo-2-(difluoromethyl)-4-fluorobenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1198171-18-4, Recommanded Product: 1198171-18-4

Step 2) Preparation of2-(difluoromethyl)-4-fluorobenzaldehyde (78): Isopropyl magnesium bromide (30 mL,l M in THF, 30 mmol) was added dropwise to an ice-cooled solution of l-bromo-2-(difluoromethyl)-4-fluorobenzene (77; 6g,26.7mmol) in THF (100 mL). The reaction mixture was then allowed to warm to room temperature and stirred for 3 hr. Dimethylformamide (3.5 mL, 45.2 mmol) was added and the reaction stirred for 3 hr. Water was added and the mixture was extracted with ethyl acetate. The combined organic layers were dried (Na2SO4) and concentrated under reduced pressure. The resulting residue was purified by chromatography to afford 2- (difluoromethyl)-4-fluorobenzaldehyde 78 (3.2g, 68%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-2-(difluoromethyl)-4-fluorobenzene, and friends who are interested can also refer to it.

Reference:
Patent; SIRTRIS PHARMACEUTICALS, INC.; WO2009/146358; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary