Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5433-01-2, name is 1-Bromo-3-isopropylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 5433-01-2
Example 3; N-{1-(3,5-Difluoro-bthetanzyl)-3-[1-ethyl-4-(3-isopropyl-phe?yl)-2-oxo-pipbetaridin-4- ylami?o]-2-hydroxy-propyl}-acbetatamide ( alternate synthesis ); Referring to Scheme 1c, intermediate compounds 14,16, 23, 24, 25, 26, 27 and the Me ester of 17 were prepared according to the following procedures:; In a 250 ml round bottom flask with reflux condenser and N2 cap, a solution of 25 gm (125.6 mmol) 1-bromo-3-isopropylbenzene and 45 gm (502.5 mmol) copper cyanide in 50 ml of pyridine was heated in a 150 0C oil bath for 2 hr where upon a dark brown homogeneous solution was formed. The reaction mixture was heated at this temperature for 11 hrs. The refluxing solution was treated with benzene and allowed to cool. The reaction mixture was partitioned between 400 ml cone NH4OH and 200 ml of benzene and was then stirred for 30 min. The mixture was poured through a small pad of silica to remove any remaining solids. The organic phase was removed and the aqueous layer was washed several times with methylene chloride. The combined organic layers were washed with saturated brine and then dried and evaporated to afford 18 gm (100%) of 3-isopropylbenzonitrile. NMR (400 MHz, CDCI3) delta 7.5-7.2 (m, 3H), 2.9 (m, 1H), 1.2 (d, 6H) ppm
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5433-01-2.
Reference:
Patent; PFIZER PRODUCTS INC.; WO2007/60526; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary