Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1252934-30-7, name is 3-(Bromomethyl)-1,1-difluorocyclobutane, A new synthetic method of this compound is introduced below., Recommanded Product: 3-(Bromomethyl)-1,1-difluorocyclobutane
10570] To 2.lh (18 mg, 0.047 mmol) was added DMF (Volume: 0.5 mE) and cesium carbonate (53.8 mg, 0.165 mmol). The reaction was stirred at room temperature for 5 minutes then 3-(bromomethyl)-1 , 1 -difluorocyclobutane (21. 83 mg, 0.118 mmol) was added. The reaction was heated to70 C. and stirred for 3 hours or until done by ECMS. The reaction was cooled, 0.5 ml of DMF was added, then filtered through a 0.45 nM in line filtet The DMF solution with the desired product 2.39a was used as is for the next step, assume quantitative yield. EC-MS (mlz): 486.4 [M+H], 0.92 mm.
The synthetic route of 1252934-30-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Novartis AG; FU, Jiping; HAN, Wooseok; KARUR, Subramanian; LU, Peichao; PFISTER, Keith Bruce; YOUNG, Joseph Michael; (97 pag.)US2018/312507; (2018); A1;,
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