Electric Literature of 75024-22-5,Some common heterocyclic compound, 75024-22-5, name is 1,4-Dibromo-2,3-dimethylbenzene, molecular formula is C8H8Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 1 Synthesis Method of Exemplary Compound A-l Exemplary Compound A-l was synthesized according to the synthesis scheme described below.; (1) Synthesis of Intermediate 1; The following reagents and solvent were placed into a reaction vessel.1, 4-dibromo-2 , 3-dimethylbenzene : 5.00 g (18.94 mmol) N-bromosuccinimide (NBS) : 7.41 g (41.63 mmol)Anhydrous carbon tetrachloride: 100 ml[0090] Next, the mixture was stirred to dissolve the solid matters, and then the following reagent was placed into the reaction vessel.Benzoyl peroxide (BPO) : 30 mg (0.12 mmol)[0091] Next, the reaction solution was stirred for 5 hours while being heated under reflux. Next, after the reaction solution was left standing to cool, insoluble matters were filtered out, and the solvent contained in the filtrate was distilled away under reduced pressure to thereby obtain a crude product. Next, the crude product was purified by a silica gel columnchromatography (developing solvent: toluene), thereby obtaining 2.98 g (yield: 37%) of Intermediate 1.
The synthetic route of 75024-22-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CANON KABUSHIKI KAISHA; OKAJIMA, Maki; YAMADA, Naoki; WO2011/40631; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary