Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19190-91-1, name is 5,6-Dibromo-1,2-dihydroacenaphthylene, A new synthetic method of this compound is introduced below., COA of Formula: C12H8Br2
An integrated flow microreactor system consisting of four T-shaped micromixers (M1,M2, M3 and M4), four microtube reactors (R1, R2, R3 and R4), and five microtube units [P1(inner diameter = 1000 m, length l = 100 cm), P2 (= 1000 m, l = 50 cm), P3 (= 1000m, l = 100 cm), P4 (= 1000 m, l = 50 cm), P5 (= 1000 m, l = 100 cm)] was used. Thewhole flow microreactor system was dipped in a water bass (24 ). A solution of 5,6-dibromoacenaphthene (0.10 M) in THF (flowrate = 6.00 mL min-1) and a solution of BuLi (0.50 M) in hexane (flow rate = 1.20 mL min-1) were introduced to M1 (= 250 m). The resulting solution was passed through R1 (phi= 500 mum, l = 3.5 cm) and was mixed with a solution of benzophenone (0.20 M) in THF (flow rate = 3.00 mL min-1) in M2 (phi= 500 mum). The resulting solution was passed through R2 (phi= 1000 mum, l = 200 cm) and was introduced to M3 (phi= 500 mum) where the solution was mixed with a solution of BuLi (0.50 M) in hexane (flow rate = 1.44 mLmin-1). The resulting solution was passed through R3 (phi= 1000 mum, l = 200 cm) and was introduced to M4 (phi= 500 mum) where the solution was mixed with a solution of 4,4′-difluorobenzophenone (0.20 M) in THF (flow rate = 3.60 mL min-1). The resulting solution was passed through R4 (phi= 1000 mum, l = 200 cm). After a steady state was reached, the product solution was collected for 130 s and was stirred for 4 h at 22 C under argon. Then the mixture was treated with BuLi (1.59 M) in hexane (6.8 mL) to consume excess ketones at -78 C. The resultant solution was further stirred for 2 h, and was treated with water.
The synthetic route of 19190-91-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Suzuki, Takanori; Uchimura, Yasuto; Nagasawa, Fumika; Takeda, Takashi; Kawai, Hidetoshi; Katoono, Ryo; Fujiwara, Kenshu; Murakoshi, Kei; Fukushima, Takanori; Nagaki, Aiichiro; Yoshida, Jun-Ichi; Chemistry Letters; vol. 43; 1; (2014); p. 86 – 88;,
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