Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 203302-95-8, name is 4-Bromo-3,5-difluoroaniline, This compound has unique chemical properties. The synthetic route is as follows., category: bromides-buliding-blocks
4-bromo-3, 5-difluoroaniline (500 mg, 2.4 mmol), 2-trifluoromethoxybenzeneboronic acid (590 mg, 2.9 mmol), Pd2(dppf)Cl2 (98 mg, 0.12 mmol), cesium carbonate (2.35 g, 7.2 mmol) and acetonitrile/water (10 mL/1 mL) were added to a microwave tube. The mixture was nitrogen sparged for 5 min, stirred and heated to 120 C for 1 hour under microwave, washed with saturated ammonium chloride (20 mL), and separated by silica gel column (petroleum ether: ethyl acetate = 50:1) to give the product of 2,6-difluoro-2?-trifluoromethoxy-[1,1?-biphenylyl]-4-amine (yellow oil, 460 mg), with a yield of 66.3%. 1H NMR (400 MHz, CDCl3) delta 7.47-7.28 (m, 4H), 6.29-6.27 (d, J= 9.1Hz, 2H), 3.67 (s, 2H). MS (ESI) m/z: 290.1 (MH+).
According to the analysis of related databases, 203302-95-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Fudan University; WANG, Yonghui; HUANG, Yafei; YU, Fazhi; TANG, Ting; EP3476829; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary