Application of 57946-63-1, The chemical industry reduces the impact on the environment during synthesis 57946-63-1, name is 2-Bromo-4-(trifluoromethyl)aniline, I believe this compound will play a more active role in future production and life.
In an air atmosphere, 1.0 mmol of o-hydroxybenzyl alcohol was added to a 10 ml flask,1.3 mmol of 4-trifluoromethyl-2-bromoaniline, 0.05 mmol of p-cymene ruthenium dichloride dimer, 0.1 mmol of cuprous chloride, 0.1 mmol of 1,1′-bis (diphenylphosphine) Ferrocene, 9.0 mmol of potassium tert-butoxide,And 5ml of xylene, and then placed on a condenser with magnetic stirring with an oil bath heated to 120 ,The reaction for 12 hours. The oil bath was removed, 3 ml of water was added to the reaction mixture, the mixture was extracted three times with 5 ml of ethyl acetate,The organic phases were combined and dried over anhydrous MgSO4 for 30 minutes and filtered; the filtrate was usedThe product was concentrated on a rotary evaporator. The concentrated solid was recrystallized from dichloromethane to give pure product 6 in 87percent yield.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-4-(trifluoromethyl)aniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Luoyang Normal College; Xu Chen; Li Hongmei; Wang Zhiqiang; Lou Xinhua; Fu Weijun; (11 pag.)CN105949143; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary