Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 58971-11-2, name is 3-Bromophenethylamine, A new synthetic method of this compound is introduced below., Application In Synthesis of 3-Bromophenethylamine
Weigh 0.382 g (2 mmol) of 3,5-dichlorosalicylaldehyde was dissolved in 30 mL of ethanol, 285 muL (2 mmol) of 3-bromophenethylamine was added dropwise and stirred under reflux for two hours. After cooling the system, 0.22 g (1 mmol) of zinc acetate dihydrate and 0.168 g (2 mmol) of sodium bicarbonate were added and the mixture was refluxed for two hours. The solution is cooled to produce a large amount of yellow precipitate.Filtered, rinsed three times with ethanol, and the precipitate was collected to give the crude product. The crude product was added to a tetrahydrofuran solution, dissolved by heating, and slowly precipitated a yellow solid at room temperature.Filtration gave product complex 2 (0.453 g, yield 55.9%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Jilin University; Men, guangwen; (14 pag.)CN104262195; (2016); B;,
Bromide – Wikipedia,
bromide – Wiktionary