Electric Literature of 1337523-99-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1337523-99-5, name is 6-Bromo-1,2,3,4-tetrahydronaphthalen-1-amine, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of amine (1.02 g, 4.5 mmol) in CH2Cl2(30 mL) was added Et3N (0.73 g, 7.22 mmol) and Boc2O (1.15 g, 5.29 mmol). The reaction solution was stirred at rt for 16 h and the mixture was concentrated in vacuo to afford a residue which was purified by silica gel chromatography (1.24 mg, yield 84%) to give a white solid. ESI-MS (M-56+H)+: 270.0.1H NMR (400 MHz, CDCl3) : 7.29-7.27 (m, 1H), 7.22-7.20 (m, 2H), 4.80-4.71 (m, 2H), 2.76-2.70 (m, 2H), 2.03-2.01 (m, 1H), 1.84-1.74 (m, 3H), 1.48 (s, 9H).
The chemical industry reduces the impact on the environment during synthesis 6-Bromo-1,2,3,4-tetrahydronaphthalen-1-amine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; BIOGEN IDEC MA INC.; SUNESIS PHARMACEUTICALS, INC.; HOPKINS, Brian T.; MA, Bin; CHAN, Timothy Raymond; KUMARAVEL, Gnanasambandam; MIAO, Hua; BERTOLOTTI-CIARLET, Andrea; OTIPOBY, Kevin; WO2015/89327; (2015); A1;,
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