New learning discoveries about 1137142-58-5

Application of 1137142-58-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1137142-58-5 as follows.

General procedure A for the preparation of intermediates 4-8; 2-Bromo-imidazo[2,1-b][1 ,3,4]thiadiazole (1 eq) and the appropriate amine (e.g. cycloprapanemethyl amine) (4.5 eq) were stirred at 135C under microwave irradiation (200W) for 5 minutes. After cooling down to room temperature, the reaction mixture was diluted with dichloromethane and purified by flash chromatography (Biotage , silica, dichloromethane:methanol) to yield the desired product (e.g. cyclopropylmethyl-imidazobeta.i-bj? .S^thiadiazol-2-yl- amine). Intermediate 4 Cyclopropylmethyl-imidazo[2,1-b][1,3,4]thiadiazoI-2-yl-amineThe title compound was obtained in 89% yield.1H NMR (300 MHz, CDCI3): delta 7.27 (brs, 1 H), 7.21 (d, J = 1.3, 1 H), 6.83 (s, 1 H), 3.01 (dd, J = 5.1 , 6.9, 2H), 1.04 – 0.80 (m, 1 H), 0.43 – 0.28 (m, 2H), 0.13 – 0.05 (m, 2H). MS (ES+) m/z 195.10 (M+H)+ (MW: 194.26).

According to the analysis of related databases, 1137142-58-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); WO2009/40552; (2009); A2;,
Bromide – Wikipedia,
bromide – Wiktionary