Related Products of 39478-78-9, A common heterocyclic compound, 39478-78-9, name is 5-Bromo-2-methylaniline, molecular formula is C7H8BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step A: N-(5-Bromo-2-methylphenyl)-2,2,2-trifluoroacetamide To a solution of 5-bromo-2-methylaniline (10 g, 54 mmol) in DCM (500 mL) was added TEA (11 mL, 81 mmol) and TFAA (9 mL, 65 mmol). After 1 h, the reaction was diluted with water. The organic phase was washed two times with water, dried over MgSO4 and concentrated to give the desired product (15 g, 99%) as a pale yellow solid. 1H NMR (400 MHz, d6-DMSO) delta 11.02 (s, 1H), 7.49 (d, J=2.0 Hz, 1H), 7.43 (dd, J=8.0 and 2.0 Hz, 1H), 7.26 (d, J=8.0 Hz, 1H), 2.13 (s, 3H) ppm.
The synthetic route of 39478-78-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Uehling, David Edward; Hubbard, Robert Dale; Waterson, Alex Gregory; Petrov, Kimberly; Bifulco, JR., Neil; Wilson, Joseph Wendell; Badiang, Jennifer Gabriel; Cheung, Mui; Yamabe, Mariko; US2009/149456; (2009); A1;,
Bromide – Wikipedia,
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