Continuously updated synthesis method about 58534-95-5

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 58534-95-5, name is 3-Bromo-2-fluoroaniline, A new synthetic method of this compound is introduced below., Quality Control of 3-Bromo-2-fluoroaniline

To a solution of 3-bromo-2-fluoroaniline (20.0 g, 105 mmol) in HC1 (12.0 M, 100 mL, 11.4 eq) was added a solution of NaN02 (10.9 g, 158 mmol, 1.50 eq) in water (20.0 mL) drop-wise at 0 C. The mixture was stirred at 0 C for 1 h. SnCl2.2H20 (71.3 g, 316 mmol, 3.00 eq) in H20 (40.0 mL) was added to the mixture at 0C. The mixture was stirred for 12 h at 20 C. The reaction mixture was filtered. The filter cake was washed with EtOAc (20.0 mL) and triturated with EtOAc (30.0 mL). The filter cake was dried to afford (3-bromo-2-fluorophenyl)hydrazine hydrochloride. LC-MS: mz 205.1 [M+H]+

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; LAMA, Lodoe; TUSCHL, Thomas; TOMITA, Daisuke; PATEL, Dinshaw; GLICKMAN, J. Fraser; KAMEI, Taku; MILLER, Michael; ASANO, Yasutomi; OKAMOTO, Rei; HASHIZUME, Shogo; AIDA, Jumpei; IMAEDA, Toshihiro; MICHINO, Mayako; KUROITA, Takanobu; (107 pag.)WO2019/153002; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary