Reference of 45762-41-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 45762-41-2, name is 4-Bromo-2-ethylaniline, This compound has unique chemical properties. The synthetic route is as follows.
4-Bromo-2-ethyl-aniline (2ml_, 14 mmol) dissolved in anhydrous pyridine (35 ml) at toom temperature was treated with methylsulfonyl chloride (1.3 ml_, 16.8 mmol). The reaction was stirred at that temperature for 15 hours before it was diluted with EtOAc. The mixture was washed with H2O, brine and dried over MgSO4. The solvent was removed in vacua and the residue was purified with flash chromatography (SiO2, 5-30% EtOAc in hexanes) to afford thedesired product (3.1 g, 81% yield). 1H NMR (300 MHz, CDCI3): 6 1.25 (t, J=7.5 Hz, 3 H), 2.61-2.68 (m, 2 H), 3.02 (s, 3 H), 6.36 (s, 1 H), 7.36-7.39 (m, 3 H).
The chemical industry reduces the impact on the environment during synthesis 4-Bromo-2-ethylaniline. I believe this compound will play a more active role in future production and life.
Reference:
Patent; PFIZER INC.; WO2006/18725; (2006); A1;,
Bromide – Wikipedia,
bromide – Wiktionary