Reference of 4549-33-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4549-33-1, name is 1,9-Dibromononane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Intermediate 163.trans-4-[(9-bromononyl)(methyl)amino]cyclohexyl 9-methyl-9H-xanthene-9- carboxylate.318 mg (0.90 mmol) of intermediate 162 are dissolved in 12 ml THF. 0.728 ml (3.61 mmol) of 1 ,9-dibromononane and 0.19 ml (1.36 mmol) of triethylamine are added and the system is stirred at 50C for 24 hr. 0.19 additioinal ml of triethylamine are added and the stirring at 50C prosecuted overnight. After a new addition of 1 ,9- dibromononane (0.911 ml; 4.5 mmol) and 72 hr of stirring at 70C the solvents are eliminated, ethyl ether is added and the solids (triethylammonium hydrobromide) filtered. The filtrate is concentrated and purified via SP1 chromatography to give 220 mg (42% yield) of the title compound.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,9-Dibromononane, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ALMIRALL, S.A.; PRAT QUINONES, Maria; FONQUERNA POU, Silvia; PUIG DURAN, Carlos; LUMERAS AMADOR, Wenceslao; AIGUADE BOSCH, Jose; CATURLA JAVALOYES, Juan Francisco; WO2011/141180; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary